Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.38 |
| ▸ | LOX | P28300 | 2/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 3/20 | 0.33 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340745 | 0.82 | MAPT (0.50) | LOXL2LOXASIC3NOS3NOS1 | |
| SCHEMBL2144434 | 0.82 | LOXL2 (0.43) | LOXL2LOXASIC3NOS3NOS1 | |
| SCHEMBL4101483 | 0.81 | TSHR (0.46) | LOXL2LOXKDM4EMEN1KMT2A | |
| SCHEMBL27854114 | 0.81 | LOXL2 (0.38) | LOXL2LOXASIC3NOS3NOS1 | |
| SCHEMBL5323724 | 0.81 | LOX (0.42) | LOXL2LOXASIC3NOS3NOS1 | |
| SCHEMBL23462840 | 0.81 | ASIC3 (0.40) | LOXL2LOXASIC3NOS3NOS1 | |
| SCHEMBL16265338 | 0.81 | LOXL2 (0.42) | LOXL2LOXASIC3NOS3NOS1 | |
| SCHEMBL940535 | 0.78 | HTR7 (0.46) | MAPT | |
| SCHEMBL171947 | 0.78 | TP53 (0.48) | LOXL2LOXASIC3NOS3NOS1 | |
| SCHEMBL29218081 | 0.76 | LOXL2 (0.40) | LOXL2LOXASIC3NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013774-A1 | BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-18 | — | — | WO | disclosed |