Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 6/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 3/20 | 0.45 |
| ▸ | CES1 | P23141 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28470106 | 1.00 | ALDH1A1 (0.75) | ALDH1A1HSP90AA1FAAHHRH3MEN1 | |
| SCHEMBL27886560 | 1.00 | ALDH1A1 (0.75) | ALDH1A1HSP90AA1FAAHHRH3MEN1 | |
| SCHEMBL23768142 | 0.94 | ALDH1A1 (0.71) | ALDH1A1HSP90AA1FAAHHRH3MEN1 | |
| SCHEMBL31216171 | 0.90 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2ALMNAPOLB | |
| SCHEMBL7885120 | 0.89 | ALDH1A1 (0.70) | ALDH1A1HSP90AA1FAAHHRH3MEN1 | |
| SCHEMBL8746080 | 0.89 | ALDH1A1 (0.70) | ALDH1A1HSP90AA1FAAHHRH3MEN1 | |
| SCHEMBL5354462 | 0.89 | ALDH1A1 (0.70) | ALDH1A1HSP90AA1FAAHHRH3MEN1 | |
| SCHEMBL14938581 | 0.89 | ALDH1A1 (0.70) | ALDH1A1HSP90AA1FAAHHRH3MEN1 | |
| SCHEMBL5592299 | 0.86 | ALDH1A1 (0.66) | ALDH1A1HSP90AA1FAAHHRH3MEN1 | |
| SCHEMBL14683501 | 0.85 | NAAA (0.58) | ALDH1A1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018014041-A2 | COMPOUNDS AND METHODS FOR MODULATION OF SMN2 | IONIS PHARMACEUTICALS, INC. (US) | 2018-01-18 | — | — | WO | disclosed |