Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 6/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ABL2 | P42684 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785505 | 0.87 | CD274 (0.47) | PDCD1CD274CDK4CCND1ABL1 | |
| SCHEMBL19785996 | 0.76 | CD274 (0.49) | PDCD1CD274 | |
| SCHEMBL19785961 | 0.75 | CD274 (0.51) | PDCD1CD274 | |
| SCHEMBL19785841 | 0.73 | PDCD1 (0.46) | PDCD1CD274 | |
| SCHEMBL29893975 | 0.71 | CD274 (0.51) | PDCD1CD274ABL1EGFRSRC | |
| SCHEMBL19779553 | 0.71 | CD274 (0.51) | PDCD1CD274ABL1EGFRSRC | |
| SCHEMBL19785820 | 0.69 | PDCD1 (0.68) | PDCD1CD274 | |
| SCHEMBL19785768 | 0.69 | PDCD1 (0.43) | PDCD1CD274KMT2A | |
| SCHEMBL19785959 | 0.69 | PDCD1 (0.51) | PDCD1CD274 | |
| SCHEMBL394743 | 0.68 | CFTR (0.57) | CDK4CCND1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013789-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2018-01-18 | — | — | WO | disclosed |