Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 9/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 9/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785996 | 0.88 | CD274 (0.49) | PDCD1CD274KDRMETCFTR | |
| SCHEMBL19785493 | 0.83 | PDCD1 (0.52) | PDCD1CD274TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL19779550 | 0.81 | PDCD1 (0.47) | PDCD1CD274TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL19785829 | 0.80 | TAS1R3 (0.46) | TAS1R3TAS1R1TAS1R2KMT2AKDR | |
| SCHEMBL19785982 | 0.79 | KDR (0.55) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL19785839 | 0.79 | PDCD1 (0.66) | PDCD1CD274KDR | |
| SCHEMBL19785841 | 0.77 | PDCD1 (0.46) | PDCD1CD274KDR | |
| SCHEMBL19785950 | 0.77 | TAS1R3 (0.45) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL19785961 | 0.70 | CD274 (0.51) | PDCD1CD274 | |
| SCHEMBL396661 | 0.70 | CFTR (0.63) | MEN1KMT2ACFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013789-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2018-01-18 | — | — | WO | disclosed |