Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 16/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 16/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19779435 | 0.81 | PDCD1 (0.51) | PDCD1CD274 | |
| SCHEMBL19785961 | 0.80 | CD274 (0.51) | PDCD1CD274 | |
| SCHEMBL19785959 | 0.79 | PDCD1 (0.51) | PDCD1CD274KDR | |
| SCHEMBL19785837 | 0.78 | KDR (0.46) | KDR | |
| SCHEMBL19785768 | 0.77 | PDCD1 (0.43) | PDCD1CD274KDR | |
| SCHEMBL19785996 | 0.77 | CD274 (0.49) | PDCD1CD274KDR | |
| SCHEMBL19785953 | 0.75 | KDR (0.45) | KDR | |
| SCHEMBL21412231 | 0.74 | PDCD1 (0.80) | PDCD1CD274 | |
| SCHEMBL31096153 | 0.74 | PDCD1 (0.80) | PDCD1CD274 | |
| SCHEMBL19785505 | 0.73 | CD274 (0.47) | PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013789-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2018-01-18 | — | — | WO | disclosed |