Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4619674 | 0.79 | PDE10A (0.38) | ERN1LMNAALDH1A1CYP2C19KDM4E | |
| SCHEMBL30601159 | 0.76 | ERN1 (0.38) | ERN1LMNAALDH1A1PTGDR2PTGS2 | |
| SCHEMBL589113 | 0.76 | LMNA (0.35) | LMNACNR1CNR2ALDH1A1KDM4E | |
| SCHEMBL20506971 | 0.74 | PDE10A (0.32) | LMNACNR1CNR2ALDH1A1KDM4E | |
| SCHEMBL20704421 | 0.74 | GRIA1 (0.33) | LMNACNR1CNR2ALDH1A1CYP1A2 | |
| SCHEMBL22703627 | 0.71 | BRD4 (0.43) | CNR1CNR2 | |
| SCHEMBL16035792 | 0.71 | CNR1 (0.33) | LMNACNR1CNR2ALDH1A1CYP2C19 | |
| SCHEMBL4941044 | 0.71 | KDM4E (0.43) | ALDH1A1CYP2C19KDM4E | |
| SCHEMBL19768916 | 0.70 | CNR1 (0.43) | LMNACNR1CNR2ALDH1A1CYP1A2 | |
| SCHEMBL16860595 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013789-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2018-01-18 | — | — | WO | disclosed |