Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 4/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22383760 | 0.84 | LMNA (0.45) | LMNACXCR4CHRM2CYP1A2SLC6A4 | |
| SCHEMBL19786041 | 0.82 | SMN1; SMN2 (0.46) | LMNAMEN1KMT2ATDP1HTR6 | |
| SCHEMBL19785978 | 0.81 | BIRC2 (0.38) | — | |
| SCHEMBL19785899 | 0.81 | LMNA (0.42) | LMNACXCR4CHRM2CYP1A2SLC6A4 | |
| SCHEMBL20804225 | 0.81 | LMNA (0.51) | LMNACXCR4CHRM2CYP1A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL21354312 | 0.80 | BIRC2 (0.37) | LMNA | |
| SCHEMBL21416735 | 0.77 | LMNA (0.59) | LMNACXCR4CHRM2CYP1A2SLC6A4 | |
| SCHEMBL7160008 | 0.77 | LMNA (0.50) | LMNACXCR4CHRM2CYP1A2SLC6A4 | |
| SCHEMBL19786040 | 0.75 | KDM4E (0.46) | LMNAMEN1KMT2A | |
| SCHEMBL30809768 | 0.74 | LMNA (0.44) | LMNACXCR4CHRM2CYP1A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484880-B1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA AS (DK) | 2020-09-02 | — | — | EP | disclosed |
| WO-2018011201-A1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2018-01-18 | — | — | WO | disclosed |