Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20614093 | 0.84 | ALDH1A1 (0.48) | SMN1; SMN2NR1H2LMNAPOLBKDM4E | |
| SCHEMBL18658612 | 0.84 | NR1H2 (0.47) | SMN1; SMN2NR1H2LMNAPOLBKDM4E | |
| SCHEMBL19785974 | 0.82 | LMNA (0.47) | LMNATDP1MEN1KMT2AHTR6 | |
| SCHEMBL27290060 | 0.80 | ALDH1A1 (0.50) | SMN1; SMN2NR1H2LMNAPOLBKDM4E | |
| SCHEMBL10084434 | 0.77 | GAA (0.55) | SMN1; SMN2NR1H2LMNAPOLBKDM4E | |
| SCHEMBL5264970 | 0.77 | GAA (0.55) | SMN1; SMN2NR1H2LMNAPOLBKDM4E | |
| SCHEMBL309875 | 0.77 | LMNA (0.49) | NR1H2LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL5265567 | 0.75 | MEN1 (0.54) | SMN1; SMN2POLBKDM4EALDH1A1TDP1 | |
| SCHEMBL23213589 | 0.74 | LMNA (0.50) | SMN1; SMN2NR1H2LMNAPOLBKDM4E | |
| SCHEMBL29716296 | 0.74 | LMNA (0.50) | SMN1; SMN2NR1H2LMNAPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018011201-A1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2018-01-18 | — | — | WO | disclosed |