Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19786025 | 0.93 | MGLL (0.33) | MGLLRORCALDH1A1KDM4ETSHR | |
| SCHEMBL22383774 | 0.92 | MGLL (0.34) | MGLLRORCALDH1A1KDM4ETSHR | |
| SCHEMBL22383731 | 0.92 | RORC (0.38) | MGLLRORCALDH1A1KDM4ETSHR | |
| SCHEMBL22383776 | 0.90 | RORC (0.34) | MGLLRORCALDH1A1KDM4ETSHR | |
| SCHEMBL19786079 | 0.88 | MGLL (0.34) | MGLLRORCALDH1A1KDM4ETSHR | |
| SCHEMBL19785619 | 0.86 | SMN1; SMN2 (0.40) | MGLLRORCALDH1A1KDM4ETSHR | |
| SCHEMBL22383780 | 0.84 | ALDH1A1 (0.40) | ALDH1A1KDM4ETSHRTP53LMNA | |
| SCHEMBL29613285 | 0.81 | RORC (0.35) | RORC | |
| SCHEMBL28722514 | 0.81 | RORC (0.35) | RORC | |
| SCHEMBL19786020 | 0.81 | RORC (0.35) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484880-B1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA AS (DK) | 2020-09-02 | — | — | EP | disclosed |
| WO-2018011201-A1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2018-01-18 | — | — | WO | disclosed |