Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19786256 | 0.89 | TSHR (0.40) | MEN1KMT2AMAPTMAPK1ALDH1A1 | |
| SCHEMBL19786484 | 0.84 | ALDH1A1 (0.34) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL19786472 | 0.83 | TRPV1 (0.33) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL19786414 | 0.82 | KMT2A (0.38) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL19786418 | 0.79 | SHMT2 (0.39) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL19786478 | 0.78 | TP53 (0.36) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL19786255 | 0.78 | GRM5 (0.37) | MAPT | |
| SCHEMBL19786411 | 0.76 | BACE1 (0.36) | MEN1KMT2AMAPT | |
| SCHEMBL19786446 | 0.76 | MAPT (0.41) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL19786416 | 0.76 | MAPT (0.37) | MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109476659-B | Novel tetrahydropyrazolopyridine compounds for the treatment of infectious diseases | 豪夫迈·罗氏有限公司 | 2021-07-09 | — | — | CN | disclosed |
| US-10781206-B2 | Tetrahydropyrazolopyridine compounds for the treatment of infectious diseases | HOFFMANN LA-ROCHE INC. (US) | 2020-09-22 | — | — | US | disclosed |
| US-10781206-B2 | Tetrahydropyrazolopyridine compounds for the treatment of infectious diseases | HOFFMANN LA-ROCHE INC. (US) | 2020-09-22 | — | — | US | disclosed |
| EP-3484883-B1 | NOVEL TETRAHYDROPYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | HOFFMANN LA ROCHE (CH) | 2020-04-15 | — | — | EP | disclosed |
| EP-3484883-B1 | NOVEL TETRAHYDROPYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | HOFFMANN LA ROCHE (CH) | 2020-04-15 | — | — | EP | disclosed |
| US-20190248786-A1 | NOVEL TETRAHYDROPYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 2019-08-15 | — | — | US | disclosed |
| WO-2018011100-A1 | NOVEL TETRAHYDROPYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10781206-B2 | Tetrahydropyrazolopyridine compounds for the treatment of infectious diseases | QDPR, TPMT, CYP3A5 | MEN1 1079/4885KMT2A 4456/4885MAPT 2652/4885 |
| US-20190248786-A1 | NOVEL TETRAHYDROPYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | QDPR, HAVCR2, TPMT | MEN1 2096/4885KMT2A 4507/4885MAPT 2683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.