Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 5/20 | 0.35 |
| ▸ | CYP46A1 | Q9Y6A2 | 11/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787091 | 0.88 | MTNR1B (0.34) | AVPR1ACYP46A1CYP3A4OPRM1AVPR1B | |
| SCHEMBL1789949 | 0.86 | CYP3A4 (0.36) | AVPR1ACYP46A1CYP3A4 | |
| SCHEMBL1791306 | 0.86 | HDAC6 (0.41) | — | |
| SCHEMBL1790522 | 0.85 | ESR2 (0.42) | — | |
| SCHEMBL1788695 | 0.83 | MLNR (0.31) | — | |
| SCHEMBL1791660 | 0.78 | CCR8 (0.34) | CYP46A1OPRM1OPRD1OPRK1 | |
| SCHEMBL1790199 | 0.78 | DRD2 (0.39) | OPRK1 | |
| SCHEMBL1978747 | 0.78 | HRH3 (0.45) | — | |
| SCHEMBL1790557 | 0.76 | ALDH1A1 (0.37) | CYP2C9CYP2C19FAAH | |
| SCHEMBL1790111 | 0.74 | GRIN2B (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326625-A1 | BENZAZEPINE DERIVATIVES AND THEIR USE AS HSTAMINE H3 ANTAGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010007382-A1 | BENZAZEPINE DERIVATIVES AND THEIR USE AS HSTAMINE H3 ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED. (JP) | 2010-01-21 | — | — | WO | disclosed |