Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.45 |
| ▸ | AKR1A1 | P14550 | 3/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1978781 | 0.85 | AKR1B1 (0.40) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL1981985 | 0.84 | BACE1 (0.40) | MAPT | |
| SCHEMBL1978029 | 0.82 | CYP3A4 (0.37) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL1978759 | 0.82 | MEN1 (0.36) | — | |
| SCHEMBL1821638 | 0.79 | CTSD (0.47) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL1977904 | 0.76 | AKR1B1 (0.35) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL1982373 | 0.74 | AKR1B1 (0.46) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL9260661 | 0.74 | AKR1B1 (0.62) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL14980632 | 0.74 | AKR1B1 (0.39) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL1820315 | 0.73 | AKR1B1 (0.39) | AKR1B1AKR1A1AKR1B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |