Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 8/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979002 | 0.85 | AKR1B1 (0.45) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL1982116 | 0.85 | MAOB (0.32) | MAOB | |
| SCHEMBL1985921 | 0.83 | BACE1 (0.39) | MAOB | |
| SCHEMBL12592579 | 0.74 | BACE1 (0.50) | — | |
| SCHEMBL12592793 | 0.74 | BACE1 (0.50) | — | |
| SCHEMBL1980452 | 0.73 | MAOB (0.43) | MAPTMAOB | |
| SCHEMBL1978029 | 0.72 | CYP3A4 (0.37) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL1981985 | 0.70 | BACE1 (0.40) | MAPT | |
| SCHEMBL1978759 | 0.68 | MEN1 (0.36) | MAOB | |
| SCHEMBL9260661 | 0.68 | AKR1B1 (0.62) | AKR1B1AKR1B10AKR1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |