Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 13/20 | 0.40 |
| ▸ | CTSD | P07339 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1982116 | 0.86 | MAOB (0.32) | BACE1CTSDITGALITGB2ICAM1 | |
| SCHEMBL1979002 | 0.84 | AKR1B1 (0.45) | MAPT | |
| SCHEMBL1983002 | 0.83 | BACE1 (0.40) | BACE1CTSDALDH1A1HPGDTP53 | |
| SCHEMBL1982797 | 0.82 | MEN1 (0.39) | BACE1CTSD | |
| SCHEMBL1985921 | 0.78 | BACE1 (0.39) | BACE1 | |
| SCHEMBL1983498 | 0.75 | BACE1 (0.47) | BACE1CTSDALDH1A1HPGDMAPT | |
| SCHEMBL1982412 | 0.75 | BACE1 (0.46) | BACE1CTSDMAPT | |
| SCHEMBL1978797 | 0.70 | BACE1 (0.46) | BACE1MAPT | |
| SCHEMBL1978518 | 0.70 | AKT1 (0.44) | ALDH1A1HPGDMAPT | |
| SCHEMBL1978781 | 0.70 | AKR1B1 (0.40) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |