SCHEMBL939491

SCHEMBL939491

CC(C)(C)OC(=O)NCC#CCCC(=O)O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN11 Q06124 1/20 0.47
MEN1 O00255 1/20 0.44
GAA P10253 1/20 0.44
KMT2A Q03164 1/20 0.44
TDP1 Q9NUW8 1/20 0.42
EPHX2 P34913 1/20 0.41
CTSK P43235 7/20 0.39
CTSS P25774 6/20 0.39
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
CTSL P07711 1/20 0.37
CTSB P07858 1/20 0.37
CHRM2 P08172 2/20 0.37
CHRM4 P08173 2/20 0.37
CHRM5 P08912 2/20 0.37
CHRM1 P11229 2/20 0.37
CHRM3 P20309 2/20 0.37
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31526439 0.90 MEN1 (0.45) PTPN11MEN1GAAKMT2ATDP1
SCHEMBL7437833 0.81 PTPN11 (0.49) PTPN11MEN1GAAKMT2ATDP1
SCHEMBL13306434 0.81 TDP1 (0.53) PTPN11MEN1GAAKMT2ATDP1
SCHEMBL24145486 0.81 MEN1 (0.46) PTPN11MEN1GAAKMT2ATDP1
SCHEMBL2396853 0.81 MEN1 (0.36) PTPN11MEN1GAAKMT2ATDP1
SCHEMBL28609057 0.80 EPHX2 (0.35) PTPN11MEN1GAAKMT2ATDP1
SCHEMBL19787903 0.80 PTPN11 (0.44) PTPN11MEN1GAAKMT2ATDP1
SCHEMBL21410149 0.78 PTPN11 (0.49) PTPN11MEN1GAAKMT2ATDP1
SCHEMBL13306409 0.77 TDP1 (0.56) PTPN11MEN1GAAKMT2ATDP1
SCHEMBL14085304 0.77 PTPN11 (0.48) PTPN11MEN1GAAKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260125418-A1 A COMPOUND AND ITS USE FOR DETECTING A DISEASE IN THE EXHALED BREATH OF A SUBJECT OWLSTONE MED LTD (GB) 2026-05-07 US disclosed
US-20260034237-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME GENMAB AS (DK) 2026-02-05 US disclosed
EP-4598592-A1 A COMPOUND AND ITS USE FOR DETECTING A DISEASE IN THE EXHALED BREATH OF A SUBJECT Owlstone Medical Limited (GB) 2025-08-13 EP disclosed
US-20240325561-A1 PEGYLATED DRUG-LINKERS FOR IMPROVED LIGAND-DRUG CONJUGATE PHARMACOKINETICS SEAGEN INC (US) 2024-10-03 US disclosed
US-20240261427-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PROFOUNDBIO US CO. 2024-08-08 US disclosed
US-20240245796-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PROFOUNDBIO US CO. 2024-07-25 US disclosed
WO-2024151890-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PROFOUNDBIO US CO. (US) 2024-07-18 WO disclosed
US-20240207418-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PROFOUNDBIO US CO. 2024-06-27 US disclosed
US-20240207429-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-06-27 US disclosed
WO-2024074813-A1 A COMPOUND AND ITS USE FOR DETECTING A DISEASE IN THE EXHALED BREATH OF A SUBJECT OWLSTONE MEDICAL LIMITED (GB) 2024-04-11 WO disclosed
EP-2928503-A1 AURISTATIN COMPOUNDS AND CONJUGATES THEREOF Mersana Therapeutics, Inc. (US) 2015-10-14 EP disclosed
WO-2015057699-A2 PEGYLATED DRUG-LINKERS FOR IMPROVED LIGAND-DRUG CONJUGATE PHARMACOKINETICS SEATTLE GENETICS, INC. (US) 2015-04-23 WO disclosed
EP-2842575-A1 Auristatin drug linker conjugates Seattle Genetics, Inc. (US) 2015-03-04 EP disclosed
EP-2265283-B1 AURISTATIN DRUG LINKER CONJUGATES SEATTLE GENETICS INC (US) 2014-09-03 EP disclosed
WO-2014093379-A1 AURISTATIN COMPOUNDS AND CONJUGATES THEREOF MERSANA THERAPEUTICS, INC. (US) 2014-06-19 WO disclosed
US-20140050746-A1 AURISTATIN DRUG LINKER CONJUGATES SEATTLE GENETICS, INC. (US) 2014-02-20 US disclosed
US-8609105-B2 Auristatin drug linker conjugates SEATTLE GENETICS, INC. (US) 2013-12-17 US disclosed
US-20110020343-A1 AURISTATIN DRUG LINKER CONJUGATES SEATTLE GENETICS, INC. (US) 2011-01-27 US disclosed
EP-2265283-A1 AURISTATIN DRUG LINKER CONJUGATES Seattle Genetics, Inc. (US) 2010-12-29 EP disclosed
WO-2009117531-A1 AURISTATIN DRUG LINKER CONJUGATES SEATTLE GENETICS, INC. (US) 2009-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260034237-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME CSGALNACT1, SLC43A1, OSTC PTPN11 1702/4885MEN1 2485/4885GAA 2914/4885
US-20240207418-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 PTPN11 3628/4885MEN1 1967/4885GAA 1776/4885
US-20110020343-A1 AURISTATIN DRUG LINKER CONJUGATES AURKA, AURKC, AURKB PTPN11 3914/4885MEN1 1046/4885GAA 3106/4885
US-20260125418-A1 A COMPOUND AND ITS USE FOR DETECTING A DISEASE IN THE EXHALED BREATH OF A SUBJECT BRCA1, L3MBTL1, LMNA PTPN11 4648/4885MEN1 35/4885GAA 588/4885
US-20140050746-A1 AURISTATIN DRUG LINKER CONJUGATES AURKA, AURKC, AURKB PTPN11 3914/4885MEN1 1046/4885GAA 3106/4885
US-20240207429-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 PTPN11 3628/4885MEN1 1967/4885GAA 1776/4885
US-20240325561-A1 PEGYLATED DRUG-LINKERS FOR IMPROVED LIGAND-DRUG CONJUGATE PHARMACOKINETICS EGFR, HDGF, CD47 PTPN11 3146/4885MEN1 4062/4885GAA 270/4885
US-20240261427-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 PTPN11 3628/4885MEN1 1967/4885GAA 1776/4885
US-20240245796-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 PTPN11 3628/4885MEN1 1967/4885GAA 1776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.