Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13306422 | 0.92 | PDPK1 (0.50) | LMNATP53RXFP1MAPTPDPK1 | |
| SCHEMBL13306583 | 0.88 | LMNA (0.51) | LMNATP53RXFP1MAPTHTT | |
| SCHEMBL13306599 | 0.87 | SMN1; SMN2 (0.47) | LMNATP53RXFP1MAPTHTT | |
| SCHEMBL19787908 | 0.85 | SMN1; SMN2 (0.50) | LMNAMAPTHTTNPSR1PDPK1 | |
| SCHEMBL13306839 | 0.84 | MAPT (0.49) | LMNATP53RXFP1MAPTHTT | |
| SCHEMBL4994990 | 0.84 | MAPT (0.50) | LMNATP53RXFP1MAPTHTT | |
| SCHEMBL19787912 | 0.83 | MAPT (0.54) | LMNATP53RXFP1MAPTSMN1; SMN2 | |
| SCHEMBL11662580 | 0.82 | KDM4E (0.59) | LMNATP53MAPTHTTPDPK1 | |
| SCHEMBL13306606 | 0.80 | KDM4E (0.68) | LMNATP53RXFP1MAPTHTT | |
| SCHEMBL13306800 | 0.80 | MAPT (0.56) | MAPTPDPK1SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |