Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | BRD2 | P25440 | 1/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2621619 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTLMNABRD4BRD2 | |
| SCHEMBL19787910 | 0.85 | LMNA (0.49) | SMN1; SMN2MAPTLMNABRD4PDPK1 | |
| SCHEMBL2621639 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTLMNABRD4BRD2 | |
| SCHEMBL13306596 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTBRD4BRD2BRD3 | |
| SCHEMBL2621620 | 0.82 | CNR1 (0.60) | SMN1; SMN2MAPTLMNABRD4BRD2 | |
| SCHEMBL19787909 | 0.81 | MAPT (0.60) | SMN1; SMN2MAPTLMNABRD4BRD2 | |
| SCHEMBL2621621 | 0.80 | ALDH1A1 (0.59) | SMN1; SMN2MAPTBRD4BRD2BRD3 | |
| SCHEMBL17477640 | 0.80 | MAPT (0.63) | SMN1; SMN2MAPTLMNABRD4BRD2 | |
| SCHEMBL4430754 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTLMNABRD4BRD2 | |
| SCHEMBL4986388 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTLMNABRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |