Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | BRD2 | P25440 | 1/20 | 0.51 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.51 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11662580 | 0.86 | KDM4E (0.59) | MAPTTP53LMNAPOLBBRD4 | |
| SCHEMBL13306606 | 0.86 | KDM4E (0.68) | MAPTTP53LMNARXFP1POLB | |
| SCHEMBL13306422 | 0.84 | PDPK1 (0.50) | MAPTTP53LMNARXFP1ALDH1A1 | |
| SCHEMBL13306839 | 0.83 | MAPT (0.49) | MAPTTP53LMNARXFP1BRD4 | |
| SCHEMBL19787909 | 0.83 | MAPT (0.60) | MAPTTP53LMNARXFP1POLB | |
| SCHEMBL19787910 | 0.83 | LMNA (0.49) | MAPTTP53LMNARXFP1BRD4 | |
| SCHEMBL13306583 | 0.82 | LMNA (0.51) | MAPTTP53LMNARXFP1BRD4 | |
| SCHEMBL4994990 | 0.81 | MAPT (0.50) | MAPTTP53LMNARXFP1TSHR | |
| SCHEMBL4986332 | 0.81 | MAPT (0.51) | MAPTTP53LMNANPC1KDM4E | |
| SCHEMBL4989937 | 0.79 | MAPT (0.46) | MAPTTP53LMNARXFP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |