Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 11/20 | 0.67 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13307444 | 0.88 | PDPK1 (0.85) | PDPK1FSCN1MAPTTP53PDE10A | |
| SCHEMBL19788469 | 0.83 | PDPK1 (0.54) | PDPK1FSCN1MAPTTP53KMT2A | |
| SCHEMBL13307445 | 0.82 | PDPK1 (0.83) | PDPK1ADRA1D | |
| SCHEMBL13333000 | 0.81 | PDPK1 (0.79) | PDPK1FSCN1MAPTTP53PDE10A | |
| SCHEMBL13307442 | 0.80 | PDPK1 (1.00) | PDPK1MAPTLMNA | |
| SCHEMBL13306406 | 0.79 | PDPK1 (1.00) | PDPK1MAPTTP53KMT2AKDM4E | |
| SCHEMBL13307448 | 0.76 | PDPK1 (0.94) | PDPK1MAPTTP53KMT2AKDM4E | |
| SCHEMBL19787940 | 0.74 | PDPK1 (0.75) | PDPK1FSCN1MAPTLMNAPDE10A | |
| SCHEMBL13307439 | 0.74 | PDPK1 (0.83) | PDPK1FSCN1PDE10A | |
| SCHEMBL13307437 | 0.72 | PDPK1 (1.00) | PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |