Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 5/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19787937 | 0.83 | PDPK1 (0.67) | PDPK1ADRA1DMAPTALDH1A1LMNA | |
| SCHEMBL13307444 | 0.81 | PDPK1 (0.85) | PDPK1MAPTBRD4TP53POLB | |
| SCHEMBL14460019 | 0.77 | BRD4 (0.69) | ADRA1DMAPTALDH1A1LMNAHPGD | |
| SCHEMBL13306405 | 0.76 | PDPK1 (0.64) | PDPK1MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL8114228 | 0.75 | ADRA1D (0.61) | ADRA1DMAPTALDH1A1LMNAHPGD | |
| SCHEMBL13307445 | 0.74 | PDPK1 (0.83) | PDPK1ADRA1DBRD4 | |
| SCHEMBL13333000 | 0.73 | PDPK1 (0.79) | PDPK1MAPTBRD4TP53POLB | |
| SCHEMBL8122767 | 0.72 | KCNH2 (0.55) | — | |
| SCHEMBL15871894 | 0.72 | PDPK1 (0.67) | PDPK1MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL18617142 | 0.71 | BRD4 (0.60) | MAPTALDH1A1LMNAHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |