Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.37 |
| ▸ | PRKCI | P41743 | 3/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.36 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.36 |
| ▸ | LATS1 | O95835 | 2/20 | 0.36 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 2/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24001454 | 0.80 | LATS1 (0.38) | LATS1 | |
| SCHEMBL19286544 | 0.77 | PRKCI (0.46) | IGF1RDYRK1BNUDT1PRKCIAXL | |
| SCHEMBL12915020 | 0.73 | PRKCI (0.49) | IGF1RDYRK1BNUDT1PRKCIAXL | |
| SCHEMBL13249593 | 0.73 | RPS6KA5 (0.42) | AXLLATS1 | |
| SCHEMBL29938802 | 0.72 | PRKCI (0.50) | IGF1RDYRK1BNUDT1PRKCIAXL | |
| SCHEMBL179480 | 0.71 | PRKCI (0.53) | IGF1RDYRK1BNUDT1PRKCIAXL | |
| SCHEMBL10298661 | 0.69 | PRKCI (0.47) | IGF1RDYRK1BNUDT1PRKCIAXL | |
| SCHEMBL20048870 | 0.69 | GPR84 (0.49) | CDK2AXLJAK3LATS1LATS2 | |
| SCHEMBL20857371 | 0.68 | NUDT1 (0.39) | IGF1RDYRK1BCDK2NUDT1PRKCI | |
| SCHEMBL20110128 | 0.67 | GPR84 (0.50) | CDK2AXLJAK3PRKACAROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873700-B2 | Compounds for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2018-01-23 | — | — | US | disclosed |