Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | RECQL | P46063 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.70 |
| ▸ | SOST | Q9BQB4 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.68 |
| ▸ | SLCO1B3 | Q9NPD5 | 4/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydroisorhamnetin SCHEMBL31237482 | 0.93 | CYP2C9 (0.78) | XDHCYP3A4ALOX15MAPTHSD17B10 | |
| Dihydroisorhamnetin SCHEMBL30915472 | 0.93 | CYP2C9 (0.78) | XDHCYP3A4ALOX15MAPTHSD17B10 | |
| Dihydroisorhamnetin SCHEMBL16887921 | 0.93 | CYP2C9 (0.78) | XDHCYP3A4ALOX15MAPTHSD17B10 | |
| Dihydroisorhamnetin SCHEMBL30255782 | 0.93 | CYP2C9 (0.78) | XDHCYP3A4ALOX15MAPTHSD17B10 | |
| Tamaraxetin SCHEMBL18235875 | 0.93 | CYP3A4 (0.73) | XDHCYP3A4ALOX15MAPTHSD17B10 | |
| Tamaraxetin SCHEMBL30256267 | 0.93 | CYP3A4 (0.73) | XDHCYP3A4ALOX15MAPTHSD17B10 | |
| Tamaraxetin SCHEMBL16887881 | 0.93 | CYP3A4 (0.73) | XDHCYP3A4ALOX15MAPTHSD17B10 | |
| SCHEMBL28024600 | 0.92 | ALDH1A1 (0.78) | XDHCYP3A4ALOX15MAPTHSD17B10 | |
| SCHEMBL21722487 | 0.89 | CYP2C9 (0.61) | XDHCYP3A4ALOX15MAPTHSD17B10 | |
| SCHEMBL4951008 | 0.88 | XDH (0.76) | XDHCYP3A4ALOX15MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392326-B9 | Silibinin component for the treatment of hepatitis | MADAUS GMBH (DE) | 2018-09-05 | — | — | EP | disclosed |
| EP-2392326-B1 | Silibinin component for the treatment of hepatitis | MADAUS GMBH (DE) | 2018-01-24 | — | — | EP | disclosed |