Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14997425 | 0.91 | SMN1; SMN2 (0.67) | HDAC2HDAC8HDAC6SMN1; SMN2HDAC1 | |
| SCHEMBL14997400 | 0.91 | SMN1; SMN2 (0.67) | HDAC2HDAC8HDAC6SMN1; SMN2HDAC1 | |
| SCHEMBL7300117 | 0.84 | HDAC2 (0.51) | HDAC2HDAC8HDAC6SMN1; SMN2RAB9A | |
| SCHEMBL3024849 | 0.83 | POLB (0.59) | MAPTALDH1A1CNR2CYP1A2KDM4E | |
| SCHEMBL3024846 | 0.83 | POLB (0.59) | MAPTALDH1A1CNR2CYP1A2KDM4E | |
| SCHEMBL13054604 | 0.83 | SMN1; SMN2 (0.50) | HDAC2HDAC8HDAC6SMN1; SMN2RAB9A | |
| SCHEMBL13054596 | 0.83 | SMN1; SMN2 (0.50) | HDAC2HDAC8HDAC6SMN1; SMN2RAB9A | |
| SCHEMBL7772333 | 0.83 | ALDH1A1 (0.66) | HDAC2HDAC8HDAC6SMN1; SMN2RAB9A | |
| SCHEMBL24114487 | 0.81 | SMN1; SMN2 (0.58) | HDAC2HDAC8HDAC6SMN1; SMN2RAB9A | |
| SCHEMBL18759290 | 0.81 | SMN1; SMN2 (0.58) | HDAC2HDAC8HDAC6SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3272749-A1 | AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE | Bayer Pharma Aktiengesellschaft (DE) | 2018-01-24 | — | — | EP | disclosed |