Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18759290 | 1.00 | SMN1; SMN2 (0.58) | SMN1; SMN2HDAC2HDAC8HDAC6POLB | |
| SCHEMBL3456224 | 0.83 | RAB9A (0.67) | SMN1; SMN2HDAC2HDAC8HDAC6POLB | |
| SCHEMBL22331980 | 0.83 | RAB9A (0.67) | SMN1; SMN2HDAC2HDAC8HDAC6POLB | |
| SCHEMBL5612230 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2HDAC2HDAC8HDAC6POLB | |
| SCHEMBL19791859 | 0.81 | HDAC2 (0.54) | SMN1; SMN2HDAC2HDAC8HDAC6MEN1 | |
| SCHEMBL24465200 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2HDAC2HDAC8HDAC6MEN1 | |
| SCHEMBL7772333 | 0.80 | ALDH1A1 (0.66) | SMN1; SMN2HDAC2HDAC8HDAC6RAB9A | |
| SCHEMBL16908173 | 0.79 | MMP2 (0.49) | HDAC2HDAC8HDAC6HTTALDH1A1 | |
| SCHEMBL7300117 | 0.79 | HDAC2 (0.51) | SMN1; SMN2HDAC2HDAC8HDAC6MEN1 | |
| SCHEMBL8091558 | 0.78 | SIGMAR1 (0.57) | SMN1; SMN2HDAC2HDAC8HDAC6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3362754-B1 | PROTEASOME INHIBITORS AND USES THEREOF | UNIV CORNELL (US) | 2021-12-22 | — | — | EP | disclosed |