Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10310085 | 0.79 | NOS3 (0.38) | NOS3NOS1NOS2RAPGEF4HRH2 | |
| SCHEMBL20669920 | 0.78 | GRM4 (0.37) | USP7ALDH1A1MAPTHSD17B10L3MBTL1 | |
| SCHEMBL91486 | 0.76 | PTGS2 (0.46) | CYP1A2CYP3A4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL9128305 | 0.75 | NOS3 (0.35) | NOS3NOS1NOS2RAPGEF4PARP1 | |
| SCHEMBL13199572 | 0.74 | NOS3 (0.48) | NOS3NOS1NOS2CYP1A2CYP3A4 | |
| SCHEMBL3580016 | 0.73 | KDM4E (0.49) | KDM4ENPC1ALDH1A1MAPTHPGD | |
| SCHEMBL24588385 | 0.73 | PTGS2 (0.38) | USP7PARP1KDM4EALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL28718520 | 0.72 | NOS3 (0.46) | NOS3NOS1NOS2CYP1A2CYP3A4 | |
| SCHEMBL25759811 | 0.72 | NOS3 (0.36) | NOS3NOS1NOS2RAPGEF4PARP1 | |
| SCHEMBL28777938 | 0.72 | PARP1 (0.51) | PARP1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3272749-A1 | AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE | Bayer Pharma Aktiengesellschaft (DE) | 2018-01-24 | — | — | EP | disclosed |