Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | ACACB | O00763 | 1/20 | 0.52 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19792936 | 0.86 | CA2 (0.60) | CA2KDM4ECTSSCTSKHPGD | |
| SCHEMBL18019210 | 0.84 | CA2 (0.57) | CA2KDM4ECTSSCTSKALDH1A1 | |
| SCHEMBL18019205 | 0.82 | LARS1 (0.61) | ACACBLARS1CTSSCTSKKAT6A | |
| SCHEMBL23568810 | 0.82 | CA2 (0.52) | CA2ACACBLARS1KDM4ECTSS | |
| SCHEMBL18019198 | 0.81 | CA2 (0.48) | CA2ACACBLARS1KDM4ECTSS | |
| SCHEMBL9895812 | 0.80 | ACACB (0.61) | ACACBLARS1ALDH1A1KAT6ARAPGEF3 | |
| SCHEMBL18019217 | 0.78 | LARS1 (0.61) | CA2LARS1KDM4ECTSSCTSK | |
| SCHEMBL18019187 | 0.77 | LARS1 (0.68) | LARS1ALDH1A1KAT6ARAPGEF3NLRP3 | |
| SCHEMBL8284970 | 0.76 | BCL2 (0.53) | CA2LARS1KDM4ECTSSCTSK | |
| SCHEMBL14074806 | 0.76 | BCL2 (0.53) | CA2LARS1KDM4ECTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11072581-B2 | N-acyl-arylsulfonamide derivatives as aminoacyl-tRNA synthetase inhibitors | Oxford Drug Design Limited (GB) | 2021-07-27 | — | — | US | disclosed |
| US-20180022696-A1 | NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS | THE LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2018-01-25 | — | — | US | disclosed |
| US-20180022696-A1 | NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS | THE LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180022696-A1 | NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS | AARS1, GARS1, ASNS | CA2 4520/4885ACACB 782/4885LARS1 72/4885 |
| US-11072581-B2 | N-acyl-arylsulfonamide derivatives as aminoacyl-tRNA synthetase inhibitors | AARS1, ASNS, GARS1 | CA2 4478/4885ACACB 790/4885LARS1 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.