Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 4/20 | 0.38 |
| ▸ | CCR8 | P51685 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22563395 | 0.92 | KDM4E (0.38) | KDM4EPDGFRBPDGFRACA12CA9 | |
| SCHEMBL19933707 | 0.92 | ALDH1A1 (0.40) | KDM4EPDGFRBPDGFRACA12CA9 | |
| SCHEMBL19933641 | 0.90 | KDM4E (0.39) | KDM4EPDGFRBPDGFRACA12CA9 | |
| SCHEMBL18015696 | 0.87 | KDM4E (0.43) | KDM4EPARP1ALDH1A1MAPTNPC1 | |
| SCHEMBL17899314 | 0.86 | CA12 (0.50) | KDM4EPDGFRBPDGFRACA12CA9 | |
| SCHEMBL19933628 | 0.85 | ALDH1A1 (0.40) | KDM4EPDGFRBPDGFRACA12CA9 | |
| SCHEMBL18015699 | 0.85 | KDM4E (0.39) | KDM4EPDGFRBPDGFRAPARP1ALDH1A1 | |
| SCHEMBL12786342 | 0.84 | KDM4E (0.54) | KDM4EPDGFRBPDGFRACA12CA9 | |
| SCHEMBL30547066 | 0.82 | KDM4E (0.62) | KDM4EPDGFRBPDGFRAPARP1ALDH1A1 | |
| SCHEMBL13019223 | 0.82 | KDM4E (0.62) | KDM4EPDGFRBPDGFRAPARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11024815-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2021-06-01 | — | — | US | disclosed |
| EP-3254317-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2019-07-31 | — | — | EP | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11024815-B2 | Metal complexes | EXOC4, EXOC3, TIMCC | KDM4E 3894/4885PDGFRB 3796/4885PDGFRA 3210/4885 |
| US-20180026209-A1 | Metal Complexes | AP3M1, AP2M1, SOD1 | KDM4E 3864/4885PDGFRB 4712/4885PDGFRA 4277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.