Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | EDNRB | P24530 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23956178 | 0.92 | NOTUM (0.60) | NOTUMMAPK1KDM4EALDH1A1PDK2 | |
| SCHEMBL17125509 | 0.85 | NOTUM (0.62) | NOTUMMAPK1KDM4EALDH1A1PDK2 | |
| SCHEMBL22915042 | 0.84 | MAPK1 (0.43) | NOTUMMAPK1KDM4EALDH1A1PDK2 | |
| SCHEMBL23956287 | 0.84 | KDM5A (0.42) | NOTUMMAPK1KDM4EALDH1A1PDK2 | |
| SCHEMBL21289803 | 0.83 | NOTUM (0.51) | NOTUMMAPK1KDM4EALDH1A1PDK2 | |
| SCHEMBL22567197 | 0.82 | LPL (0.40) | NOTUMMAPK1KDM4EALDH1A1PDK2 | |
| SCHEMBL22030032 | 0.81 | NOTUM (0.50) | NOTUMMAPK1KDM4EALDH1A1PDK2 | |
| SCHEMBL514359 | 0.81 | NOTUM (0.62) | NOTUMMAPK1KDM4EALDH1A1PDK2 | |
| SCHEMBL23956273 | 0.81 | GRM5 (0.39) | NOTUMMAPK1KDM4EALDH1A1PDK2 | |
| SCHEMBL23956203 | 0.81 | CCR1 (0.43) | NOTUMKDM4EALDH1A1EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11024815-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2021-06-01 | — | — | US | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11024815-B2 | Metal complexes | EXOC4, EXOC3, TIMCC | NOTUM 3607/4885MAPK1 4689/4885KDM4E 3894/4885 |
| US-20180026209-A1 | Metal Complexes | AP3M1, AP2M1, SOD1 | NOTUM 3709/4885MAPK1 4164/4885KDM4E 3864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.