Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 8/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.45 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1822778 | 0.82 | AKR1B1 (0.47) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL7958615 | 0.80 | AKR1B1 (0.43) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL25892734 | 0.79 | AKR1B1 (0.63) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL1978738 | 0.77 | AKR1B1 (0.48) | AKR1B1AKR1B10AKR1A1BACE1MAPT | |
| SCHEMBL1823883 | 0.76 | AKR1B1 (0.48) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL9181175 | 0.76 | AKR1B1 (0.65) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL25893192 | 0.76 | AKR1B1 (0.75) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL10487420 | 0.74 | AKR1B1 (0.66) | AKR1B1 | |
| SCHEMBL9818912 | 0.74 | AKR1B1 (0.66) | AKR1B1 | |
| SCHEMBL9818906 | 0.74 | AKR1B1 (0.66) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |