Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | BCR | P11274 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1984174 | 0.96 | ABL1 (0.49) | ABL1BCRPADI4MAPK9MAPKAPK2 | |
| SCHEMBL1980317 | 0.92 | PDPK1 (0.49) | ABL1BCRHRH3PDPK1CYP2D6 | |
| SCHEMBL1983423 | 0.89 | ABL1 (0.47) | ABL1BCRKDRPDPK1TLR8 | |
| SCHEMBL1979784 | 0.87 | PKM (0.47) | — | |
| SCHEMBL1984242 | 0.85 | EPHX2 (0.46) | ABL1BCRPADI4HRH3EPHX2 | |
| SCHEMBL1980602 | 0.82 | ABL1 (0.45) | ABL1BCRTLR8TLR7 | |
| SCHEMBL1980375 | 0.82 | JAK2 (0.45) | ABL1BCRJAK2JAK1JAK3 | |
| SCHEMBL1979037 | 0.81 | NEK1 (0.48) | ABL1BCRKDRCYP2D6TLR8 | |
| SCHEMBL1561132 | 0.81 | PADI4 (0.47) | ABL1BCRPADI4EPHX2CYP2D6 | |
| SCHEMBL2217947 | 0.80 | CHEK1 (0.62) | ABL1BCRHRH3EPHX2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | claimed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |