Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | BCR | P11274 | 2/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979037 | 0.92 | NEK1 (0.48) | ABL1BCRPIM1PIM3PIM2 | |
| SCHEMBL1979697 | 0.87 | TLR8 (0.40) | PIM1PIM3PIM2NEK1CLK2 | |
| SCHEMBL1980257 | 0.85 | PIM1 (0.52) | PIM1PIM3PIM2CLK2DYRK1A | |
| SCHEMBL1983423 | 0.85 | ABL1 (0.47) | ABL1BCRCHRNB2CHRNA4PIM1 | |
| SCHEMBL1982709 | 0.84 | TLR8 (0.48) | ABL1BCRPIM1PIM3PIM2 | |
| SCHEMBL1981277 | 0.84 | WNT1 (0.49) | ABL1BCRDYRK1AWNT1TLR8 | |
| SCHEMBL1980317 | 0.84 | PDPK1 (0.49) | ABL1BCRTLR8TLR7 | |
| SCHEMBL1980014 | 0.84 | TLR7 (0.49) | ABL1BCRPIM1PIM3PIM2 | |
| SCHEMBL1984174 | 0.83 | ABL1 (0.49) | ABL1BCRNPC1RAB9ATGFBR1 | |
| SCHEMBL1978130 | 0.82 | TLR7 (0.48) | ABL1BCRDYRK1AWNT1TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |