Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11069168 | 0.80 | CSNK2A1 (0.58) | MEN1KMT2ACYP2D6RAB9ACSNK2A1 | |
| SCHEMBL1341532 | 0.79 | MAPT (0.49) | MEN1KMT2ACYP2D6NPC1RAB9A | |
| SCHEMBL12442147 | 0.78 | KMT2A (0.50) | MEN1KMT2ACYP2D6NPC1RAB9A | |
| SCHEMBL27992485 | 0.77 | MAPT (0.49) | MEN1KMT2ANPC1CSNK2A1F2R | |
| SCHEMBL1347939 | 0.75 | RAB9A (0.55) | MEN1KMT2ACYP2D6HPGDNPC1 | |
| SCHEMBL5329509 | 0.75 | KMT2A (0.44) | MEN1KMT2ACYP2D6NPC1RAB9A | |
| SCHEMBL136961 | 0.75 | F2R (0.47) | MEN1KMT2ANPC1CSNK2A1F2R | |
| SCHEMBL30844550 | 0.75 | F2R (0.47) | MEN1KMT2ANPC1CSNK2A1F2R | |
| SCHEMBL500361 | 0.75 | CSNK2A1 (0.61) | MEN1KMT2ANPC1CSNK2A1F2R | |
| SCHEMBL3735051 | 0.73 | CSNK2A1 (0.44) | MEN1KMT2ANPC1RAB9ACSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018015410-A1 | BICYCLIC PROLINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-25 | — | — | WO | disclosed |