Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 11/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19795019 | 0.82 | PTGS2 (0.37) | TRPA1PTGS2POLB | |
| SCHEMBL16648002 | 0.82 | TRPA1 (0.45) | TRPA1PTGS2TRPV4 | |
| SCHEMBL12424374 | 0.80 | POLB (0.54) | TRPA1PTGS2POLB | |
| SCHEMBL26136150 | 0.78 | PTGS2 (0.42) | PTGS2POLB | |
| SCHEMBL1002604 | 0.78 | PTGS2 (0.42) | PTGS2POLB | |
| SCHEMBL14304515 | 0.78 | PTGS2 (0.58) | PTGS2POLB | |
| SCHEMBL20997430 | 0.77 | TRPA1 (0.45) | TRPA1 | |
| SCHEMBL19795387 | 0.75 | TRPA1 (0.48) | TRPA1TRPV4DHFR | |
| SCHEMBL19795021 | 0.75 | TRPA1 (0.50) | TRPA1TRPV4 | |
| SCHEMBL16043755 | 0.74 | KCNJ1 (0.39) | TRPA1TRPV4POLBDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487853-B1 | BICYCLIC PROLINE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2022-06-08 | — | — | EP | disclosed |
| EP-3487853-B1 | BICYCLIC PROLINE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2022-06-08 | — | — | EP | disclosed |
| CN-109476640-B | Bicyclic proline compounds | 豪夫迈·罗氏有限公司 | 2022-02-25 | — | — | CN | disclosed |
| CN-109476628-B | Sulfonylcycloalkylamide compounds as TRPA1 modulators | 豪夫迈·罗氏有限公司 | 2022-01-11 | — | — | CN | disclosed |
| US-10766878-B2 | Sulfonylcycloalkyl carboxamide compounds | GENENTECH, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-10766878-B2 | Sulfonylcycloalkyl carboxamide compounds | GENENTECH, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-10597383-B2 | Bicyclic proline compounds | GENENTECH, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20190144430-A1 | SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS | GENENTECH, INC. (US) | 2019-05-16 | — | — | US | disclosed |
| US-20190144428-A1 | BICYCLIC PROLINE COMPOUNDS | GENENTECH, INC. (US) | 2019-05-16 | — | — | US | disclosed |
| US-20190144428-A1 | BICYCLIC PROLINE COMPOUNDS | GENENTECH, INC. (US) | 2019-05-16 | — | — | US | disclosed |
| US-20190144430-A1 | SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS | GENENTECH, INC. (US) | 2019-05-16 | — | — | US | disclosed |
| WO-2018015411-A1 | SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS AS TRPA1 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-25 | — | — | WO | disclosed |
| WO-2018015410-A1 | BICYCLIC PROLINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144430-A1 | SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS | TRPA1, TRPV1, TRPV5 | TRPA1 1/4885PTGS2 676/4885TRPV4 7/4885 |
| US-10597383-B2 | Bicyclic proline compounds | TRPA1, TRPV1, TRPV5 | TRPA1 1/4885PTGS2 132/4885TRPV4 8/4885 |
| US-20190144428-A1 | BICYCLIC PROLINE COMPOUNDS | TRPA1, TRPV1, TRPV5 | TRPA1 1/4885PTGS2 132/4885TRPV4 8/4885 |
| US-10766878-B2 | Sulfonylcycloalkyl carboxamide compounds | TRPA1, TRPV1, TRPV5 | TRPA1 1/4885PTGS2 676/4885TRPV4 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.