Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635237 | 0.87 | TSHR (0.54) | TAAR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL31612527 | 0.82 | CYP2C19 (0.55) | OPRK1ALDH1A1KCNH2SIGMAR1CNR2 | |
| SCHEMBL3160936 | 0.80 | MAOB (0.52) | TAAR1OPRK1ALDH1A1KCNH2SIGMAR1 | |
| SCHEMBL12124877 | 0.77 | TSHR (0.50) | HRH3OPRK1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL12902355 | 0.76 | TAAR1 (0.75) | TAAR1HDAC1PYCR1HRH3ALDH1A1 | |
| SCHEMBL5915632 | 0.76 | TAAR1 (1.00) | TAAR1HDAC3HDAC1HDAC2PYCR1 | |
| SCHEMBL10746744 | 0.75 | AOC3 (0.47) | HRH3OPRK1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL629059 | 0.74 | MAPT (0.47) | HDAC3HDAC6PYCR1ALDH1A1 | |
| SCHEMBL16312132 | 0.74 | SLC6A2 (0.48) | TAAR1PYCR1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL16312137 | 0.74 | PYCR1 (0.46) | TAAR1HDAC3HDAC6PYCR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10385004-B2 | Process and intermediates for the preparation of NEP inhibitors | NOVARTIS AG (CH) | 2019-08-20 | — | — | US | disclosed |
| US-20180022690-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF NEP INHIBITORS | NOVARTIS PHARMA AG (CH) | 2018-01-25 | — | — | US | disclosed |
| US-20180022690-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF NEP INHIBITORS | NOVARTIS PHARMA AG (CH) | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385004-B2 | Process and intermediates for the preparation of NEP inhibitors | MME, ACE, REN | TAAR1 1932/4885HDAC3 1435/4885HDAC4 1940/4885 |
| US-20180022690-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF NEP INHIBITORS | MME, ACE, REN | TAAR1 1932/4885HDAC3 1435/4885HDAC4 1940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.