Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL614112 | 0.84 | HRH3 (0.38) | HTR2ACHRNB2CHRNA4 | |
| SCHEMBL1978631 | 0.83 | HTR2A (0.44) | HTR2ASIGMAR1 | |
| SCHEMBL8130889 | 0.78 | HTR2A (0.55) | HTR2ASIGMAR1GRM5 | |
| SCHEMBL614587 | 0.78 | KCNH2 (0.39) | CHRNB2CHRNA4 | |
| SCHEMBL482776 | 0.77 | NPSR1 (0.39) | HTR2ACHRNB2CHRNA4 | |
| SCHEMBL8114656 | 0.75 | KCNH2 (0.47) | — | |
| SCHEMBL8122306 | 0.75 | KCNH2 (0.47) | — | |
| SCHEMBL8122540 | 0.75 | KCNH2 (0.47) | — | |
| SCHEMBL6293461 | 0.74 | CHRNB2 (0.50) | HTR2ASIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL1984212 | 0.73 | HAO1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | claimed |
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |