Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.34 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL614587 | 0.89 | KCNH2 (0.39) | CYP2D6CHRNB2CHRNA4CYP1A2CYP3A4 | |
| SCHEMBL8122540 | 0.86 | KCNH2 (0.47) | CYP3A4KCNH2 | |
| SCHEMBL8122306 | 0.86 | KCNH2 (0.47) | CYP3A4KCNH2 | |
| SCHEMBL8114656 | 0.86 | KCNH2 (0.47) | CYP3A4KCNH2 | |
| SCHEMBL482776 | 0.85 | NPSR1 (0.39) | CHRNB2CHRNA4GABRPGABRDGABRA1 | |
| SCHEMBL1979835 | 0.84 | HTR2A (0.35) | CHRNB2CHRNA4HTR2A | |
| SCHEMBL8728334 | 0.78 | GABRP (0.41) | HRH3CYP2D6CHRNB2CHRNA4GABRP | |
| SCHEMBL6293461 | 0.78 | CHRNB2 (0.50) | CHRNB2CHRNA4NPSR1CYP1A2CYP3A4 | |
| SCHEMBL6296436 | 0.77 | ALDH1A1 (0.38) | HRH3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1978631 | 0.76 | HTR2A (0.44) | HAO1CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427417-B1 | SALTS OF 3-PENTYLPHENYLACETIC ACID AND PHARMACEUTICAL USES THEREOF | PROMETIC BIOSCIENCES INC (CA) | 2013-10-09 | — | — | EP | claimed |
| US-20160367639-A1 | MODIFICATION OF FEEDING BEHAVIOR | IMPERIAL INNOVATIONS LIMITED (GB) | 2016-12-22 | — | — | US | disclosed |
| EP-2329839-B1 | Modification of feeding behavior by GLP-1 and PYY | IMP INNOVATIONS LTD (GB) | 2015-09-16 | — | — | EP | disclosed |
| US-20150051140-A1 | MODIFICATION OF FEEDING BEHAVIOR | IMPERIAL INNOVATIONS (GB) | 2015-02-19 | — | — | US | disclosed |
| CN-103347509-A | Compounds and compositions for the treatment of cancer | PROMETIC BIOSCIENCES INC | 2013-10-09 | — | — | CN | disclosed |
| US-8217001-B2 | Modification of feeding behavior | IMPERIAL INNOVATIONS LIMITED | 2012-07-10 | — | — | US | disclosed |
| CN-102421742-A | Salts of 3-pentylphenylacetic acid and pharmaceutical uses thereof | PROMETIC BIOSCIENCES INC | 2012-04-18 | — | — | CN | disclosed |
| US-20120040893-A1 | MODIFICATION OF FEEDING BEHAVIOUR | COWLEY MICHAEL (AU) | 2012-02-16 | — | — | US | disclosed |
| US-8058233-B2 | adminsteration of Peptide YY and glucagons-like peptide-1( GLP-1) or agonists to a overweight subject, or having obesity related disorders, results in decreased food intake, caloric intake, appetite, and an alteration in energy metabolism | OREGON HEALTH AND SCIENCE UNIVERSITY (US) | 2011-11-15 | — | — | US | disclosed |
| EP-2329839-A1 | Modification of feeding behavior by GLP-1 and PYY | Imperial Innovations Limited (GB) | 2011-06-08 | — | — | EP | disclosed |
| EP-1137631-B1 | REVERSIBLE AQUEOUS pH SENSITIVE LIPIDIZING REAGENTS, COMPOSITIONS AND METHODS OF USE | UNIV SOUTHERN CALIFORNIA (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003057235-A2 | MODIFICATION OF FEEDING BEHAVIOR | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2003-07-17 | — | — | WO | disclosed |
| US-6590071-B1 | Increasing the delivery of hydrophilic amine containing compounds to the cell having a mucosal barrier, in which a compound of given formula penetrates the mucosal barrier of the cell; free amine is liberated by hydrolysis | UNIVERSITY OF SOUTHERN CALIFORNIA | 2003-07-08 | — | — | US | disclosed |
| WO-2003027637-A2 | ASSESSMENT OF NEURONS IN THE ARCUATE NUCLEUS TO SCREEN FOR AGENTS THAT MODIFY FEEDING BEHAVIOR | OREGON HEALTH AND SCIENCE UNIVERSITY (US) | 2003-04-03 | — | — | WO | disclosed |
| WO-2003026591-A2 | MODIFICATION OF FEEDING BEHAVIOR | IMPERIAL COLLEGE INNOVATIONS LTD. (GB) | 2003-04-03 | — | — | WO | disclosed |
| EP-1137631-A1 | REVERSIBLE AQUEOUS pH SENSITIVE LIPIDIZING REAGENTS, COMPOSITIONS AND METHODS OF USE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000034236-A1 | REVERSIBLE AQUEOUS pH SENSITIVE LIPIDIZING REAGENTS, COMPOSITIONS AND METHODS OF USE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2000-06-15 | — | — | WO | disclosed |
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051140-A1 | MODIFICATION OF FEEDING BEHAVIOR | GLP1R, NPY4R, NPY1R | HRH3 906/4885CYP2D6 4769/4885CHRNB2 284/4885 |
| US-20120040893-A1 | MODIFICATION OF FEEDING BEHAVIOUR | GLP1R, NPY4R, NPY1R | HRH3 788/4885CYP2D6 4728/4885CHRNB2 295/4885 |
| US-20160367639-A1 | MODIFICATION OF FEEDING BEHAVIOR | GLP1R, NPY4R, NPY1R | HRH3 906/4885CYP2D6 4769/4885CHRNB2 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.