Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 10/20 | 0.88 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.88 |
| ▸ | PGR | P06401 | 6/20 | 0.88 |
| ▸ | LMNA | P02545 | 5/20 | 0.88 |
| ▸ | AR | P10275 | 3/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | MEN1 | O00255 | 1/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.81 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluocinonide SCHEMBL2962841 | 0.94 | HIF1A (1.00) | NR3C1HIF1APGRLMNAAR | |
| Fluocinonide SCHEMBL13026147 | 0.94 | HIF1A (1.00) | NR3C1HIF1APGRLMNAAR | |
| Fluocinonide SCHEMBL2800723 | 0.94 | HIF1A (1.00) | NR3C1HIF1APGRLMNAAR | |
| Fluocinonide SCHEMBL13072779 | 0.94 | HIF1A (1.00) | NR3C1HIF1APGRLMNAAR | |
| Fluocinonide SCHEMBL9338347 | 0.94 | HIF1A (1.00) | NR3C1HIF1APGRLMNAAR | |
| Fluocinonide SCHEMBL13072509 | 0.94 | HIF1A (1.00) | NR3C1HIF1APGRLMNAAR | |
| Fluocinonide SCHEMBL4262 | 0.94 | HIF1A (1.00) | NR3C1HIF1APGRLMNAAR | |
| Fluocinonide SCHEMBL13568069 | 0.94 | HIF1A (1.00) | NR3C1HIF1APGRLMNAAR | |
| Fluocinonide SCHEMBL2895156 | 0.93 | HIF1A (0.98) | NR3C1HIF1APGRLMNAAR | |
| Fluocinonide SCHEMBL28118986 | 0.93 | NR3C1 (0.98) | NR3C1HIF1APGRLMNAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012435-B2 | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology | NICOX S.A. (FR) | 2015-04-21 | — | — | US | disclosed |
| US-9012435-B2 | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology | NICOX S.A. (FR) | 2015-04-21 | — | — | US | disclosed |
| US-20130303499-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NICOX S.A. (FR) | 2013-11-14 | — | — | US | disclosed |
| US-20130303499-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NICOX S.A. (FR) | 2013-11-14 | — | — | US | disclosed |
| US-8518920-B2 | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology | NICOX S.A. (FR) | 2013-08-27 | — | — | US | disclosed |
| US-8518920-B2 | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology | NICOX S.A. (FR) | 2013-08-27 | — | — | US | disclosed |
| US-8518920-B2 | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology | NICOX S.A. (FR) | 2013-08-27 | — | — | US | disclosed |
| US-20110144073-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NICOX S.A. | 2011-06-16 | — | — | US | disclosed |
| US-20110144073-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NICOX S.A. | 2011-06-16 | — | — | US | disclosed |
| US-20110144073-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NICOX S.A. | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144073-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NR3C1, NR3C2, CYP11B1 | NR3C1 1/4885HIF1A 2532/4885PGR 174/4885 |
| US-20130303499-A1 | GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY | NR3C1, NR3C2, CYP11B1 | NR3C1 1/4885HIF1A 2532/4885PGR 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.