Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluocinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 8/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | PGR | P06401 | 5/20 | 1.00 |
| ▸ | AR | P10275 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.81 |
| ▸ | MAPT | P10636 | 2/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | CNR1 | P21554 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluocinonide SCHEMBL13072779 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL2800723 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL13072509 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL13568069 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL4262 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL9338347 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL2962841 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL2895156 | 0.99 | HIF1A (0.98) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL28118986 | 0.99 | NR3C1 (0.98) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL28089918 | 0.97 | NR3C1 (0.94) | HIF1ANR3C1LMNAPGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230108050-A1 | CXCL8 (INTERLEUKIN-8) ACTIVITY INHIBITOR AND CORTICOSTEROID COMBINATION AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | DOMPE' FARMACEUTICI SPA (IT) | 2023-04-06 | — | — | US | claimed |
| EP-4106738-A1 | CXCL8 (INTERLEUKIN-8) ACTIVITY INHIBITOR AND CORTICOSTEROID COMBINATION AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Dompe' Farmaceutici SpA (IT) | 2022-12-28 | — | — | EP | claimed |
| CN-115484943-A | Combination of CXCL8 (interleukin-8) activity inhibitor and corticosteroid, pharmaceutical composition and use thereof | 导博药物公司 | 2022-12-16 | — | — | CN | claimed |
| CN-118974034-A | Pest control agent | 日本化药株式会社 | 2024-11-15 | — | — | CN | disclosed |
| US-20230108050-A1 | CXCL8 (INTERLEUKIN-8) ACTIVITY INHIBITOR AND CORTICOSTEROID COMBINATION AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | DOMPE' FARMACEUTICI SPA (IT) | 2023-04-06 | — | — | US | disclosed |
| EP-4106738-A1 | CXCL8 (INTERLEUKIN-8) ACTIVITY INHIBITOR AND CORTICOSTEROID COMBINATION AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Dompe' Farmaceutici SpA (IT) | 2022-12-28 | — | — | EP | disclosed |
| CN-115484943-A | Combination of CXCL8 (interleukin-8) activity inhibitor and corticosteroid, pharmaceutical composition and use thereof | 导博药物公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-115484826-A | Compositions and methods for controlling fungal diseases in plants | FMC公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-115380909-A | Synergistic fungicidal mixtures for controlling fungi in cereals | 阿达玛马克西姆股份有限公司 | 2022-11-25 | — | — | CN | disclosed |
| US-20140309398-A1 | OLIGOMER-CORTICOSTEROID CONJUGATES | NEKTAR THERAPEUTICS | 2014-10-16 | — | — | US | disclosed |
| US-20140309398-A1 | OLIGOMER-CORTICOSTEROID CONJUGATES | NEKTAR THERAPEUTICS | 2014-10-16 | — | — | US | disclosed |
| US-8796248-B2 | Oligomer-corticosteroid conjugates | NEKTAR THERAPEUTICS (US) | 2014-08-05 | — | — | US | disclosed |
| US-8796248-B2 | Oligomer-corticosteroid conjugates | NEKTAR THERAPEUTICS (US) | 2014-08-05 | — | — | US | disclosed |
| US-20100286107-A1 | Oligomer-Corticosteroid Conjugates | NEKTAR THERAPEUTICS (US) | 2010-11-11 | — | — | US | disclosed |
| US-20100286107-A1 | Oligomer-Corticosteroid Conjugates | NEKTAR THERAPEUTICS (US) | 2010-11-11 | — | — | US | disclosed |
| US-20100056488-A1 | CORTICOSTEROID CONJUGATES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2010-03-04 | — | — | US | disclosed |
| US-20100056488-A1 | CORTICOSTEROID CONJUGATES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2010-03-04 | — | — | US | disclosed |
| WO-2009045539-A2 | OLIGOMER-CORTICOSTEROID CONJUGATES | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230108050-A1 | CXCL8 (INTERLEUKIN-8) ACTIVITY INHIBITOR AND CORTICOSTEROID COMBINATION AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | CXCL8, CCR8, MMP8 | NR3C1 91/4885HIF1A 2536/4885LMNA 4459/4885 |
| US-20100056488-A1 | CORTICOSTEROID CONJUGATES AND USES THEREOF | NR3C1, NR3C2, C3AR1 | NR3C1 1/4885HIF1A 4459/4885LMNA 2646/4885 |
| US-20100286107-A1 | Oligomer-Corticosteroid Conjugates | SERPINA6, NR3C2, NR3C1 | NR3C1 3/4885HIF1A 4786/4885LMNA 4428/4885 |
| US-20140309398-A1 | OLIGOMER-CORTICOSTEROID CONJUGATES | SERPINA6, NR3C1, NR3C2 | NR3C1 2/4885HIF1A 4721/4885LMNA 4598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.