Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluocinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 8/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | PGR | P06401 | 5/20 | 1.00 |
| ▸ | AR | P10275 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.81 |
| ▸ | MAPT | P10636 | 2/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | CNR1 | P21554 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluocinonide SCHEMBL13072779 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL13026147 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL2800723 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL13072509 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL13568069 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL4262 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL2962841 | 1.00 | HIF1A (1.00) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL2895156 | 0.99 | HIF1A (0.98) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL28118986 | 0.99 | NR3C1 (0.98) | HIF1ANR3C1LMNAPGRAR | |
| Fluocinonide SCHEMBL28089918 | 0.97 | NR3C1 (0.94) | HIF1ANR3C1LMNAPGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609998-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | Frequency Therapeutics, Inc. (US) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018191350-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | Frequency Therapeutics, Inc. (US) | 2018-10-18 | — | — | WO | disclosed |
| EP-0277211-B1 | POLYMERIC CARRIER COMPOSITIONS AND METHODS FOR THEIR PREPARATION AND USE | ADVANCED POLYMER SYSTEMS INC (US) | 1994-06-01 | — | — | EP | disclosed |
| EP-0277211-A4 | POLYMERIC CARRIER COMPOSITIONS AND METHODS FOR THEIR PREPARATION AND USE | — | 1990-09-05 | — | — | EP | disclosed |
| EP-0277211-A1 | POLYMERIC CARRIER COMPOSITIONS AND METHODS FOR THEIR PREPARATION AND USE. | ADVANCED POLYMER SYSTEMS INC (US) | 1988-08-10 | — | — | EP | disclosed |
| WO-1988001164-A1 | POLYMERIC CARRIER COMPOSITIONS AND METHODS FOR THEIR PREPARATION AND USE | ADVANCED POLYMER SYSTEMS, INC. (US) | 1988-02-25 | — | — | WO | disclosed |