Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21789124 | 0.82 | EPHX2 (0.47) | POLBMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL26981939 | 0.80 | NPSR1 (0.48) | POLBMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL16839934 | 0.80 | OPRM1 (0.44) | POLBMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL16838934 | 0.79 | SMN1; SMN2 (0.47) | MEN1KMT2AMAPTSMN1; SMN2OPRM1 | |
| SCHEMBL16839728 | 0.78 | POLB (0.53) | POLBMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL1616598 | 0.78 | PDCD1 (0.43) | MEN1KMT2AMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL16838968 | 0.78 | CTSL (0.44) | MEN1KMT2AMAPTSMN1; SMN2OPRM1 | |
| SCHEMBL1976788 | 0.77 | SMN1; SMN2 (0.55) | POLBMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL16112268 | 0.76 | KDM4E (0.43) | MEN1KMT2AMAPTSMN1; SMN2OPRM1 | |
| Hydrochloric Acid SCHEMBL29927800 | 0.76 | ALDH1A1 (0.45) | POLBMEN1KMT2AMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509981-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Eli Lilly and Company (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011071840-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | ELI LILLY AND COMPANY (US) | 2011-06-16 | — | — | WO | disclosed |