Styrene

Styrene

SCHEMBL1980399

C=CC#N.C=Cc1ccccc1.CC(=O)O

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.54
TSHR P16473 2/20 0.54
TDP1 Q9NUW8 2/20 0.42
AKR1C3 P42330 1/20 0.42
GLA P06280 1/20 0.42
MCL1 Q07820 2/20 0.41
MAPT P10636 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
RECQL P46063 2/20 0.37
CYP2C19 P33261 1/20 0.37
AKT1 P31749 1/20 0.36
HDAC3 O15379 1/20 0.36
TNKS O95271 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HCAR2 Q8TDS4 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Styrene SCHEMBL10804465 0.96 ALDH1A1 (0.50) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL2475762 0.94 ALDH1A1 (0.52) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL4375720 0.92 ALDH1A1 (0.58) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL295031 0.91 ALDH1A1 (0.48) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL9567884 0.90 ALDH1A1 (0.56) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL28156438 0.90 ALDH1A1 (0.47) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL7699411 0.90 ALDH1A1 (0.47) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL3789273 0.89 ALDH1A1 (0.54) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL157052 0.89 ALDH1A1 (0.54) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL27670716 0.89 ALDH1A1 (0.54) ALDH1A1TSHRTDP1AKR1C3GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190161027-A1 IRIDESCENT VEHICULAR TRIM ASSEMBLIES AND MULTI-SHOT INJECTION MOLDING METHODS FOR MAKING THE SAME FORD GLOBAL TECHNOLOGIES, LLC (US) 2019-05-30 US disclosed
US-10239471-B2 Iridescent vehicular trim assemblies and multi-shot injection molding methods for making the same FORD GLOBAL TECHNOLOGIES, LLC (US) 2019-03-26 US disclosed
US-20180111570-A1 IRIDESCENT VEHICULAR TRIM ASSEMBLIES AND MULTI-SHOT INJECTION MOLDING METHODS FOR MAKING THE SAME FORD GLOBAL TECHNOLOGIES, LLC (US) 2018-04-26 US disclosed
US-20160303836-A1 HEAT BUILD-UP AND COLOR FADE RESISTANT VINYL EXTRUDATE DEUTSCHE BANK AG NEW YORK BRANCH, AS SUCCESSOR COLLATERAL AGENT 2016-10-20 US disclosed
US-20110145966-A1 FACE SHIELD AND METHOD FOR ITS MANUFACTURE BENVENUTO GUIDO 2011-06-23 US disclosed
US-20080000001-A1 FACE SHIELD AND METHOD FOR ITS MANUFACTURE WINDSOR MOLD, INC. (CA) 2008-01-03 US disclosed