Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL157052 | 0.96 | ALDH1A1 (0.54) | ALDH1A1TSHRMCL1PLIN1LMNA | |
| Styrene SCHEMBL27190847 | 0.94 | ALDH1A1 (0.52) | ALDH1A1TSHRMCL1PLIN1LMNA | |
| Styrene SCHEMBL123961 | 0.92 | ALDH1A1 (0.54) | ALDH1A1TSHRMCL1PLIN1LMNA | |
| Styrene SCHEMBL1980399 | 0.92 | ALDH1A1 (0.54) | ALDH1A1TSHRMCL1PLIN1LMNA | |
| Styrene SCHEMBL3789273 | 0.92 | ALDH1A1 (0.54) | ALDH1A1TSHRMCL1PLIN1LMNA | |
| Styrene SCHEMBL27670716 | 0.92 | ALDH1A1 (0.54) | ALDH1A1TSHRMCL1PLIN1LMNA | |
| Styrene SCHEMBL21697 | 0.91 | ALDH1A1 (0.70) | ALDH1A1TSHRMCL1LMNAHDAC8 | |
| Styrene SCHEMBL10592601 | 0.91 | ALDH1A1 (0.70) | ALDH1A1TSHRMCL1LMNAHDAC8 | |
| Styrene SCHEMBL5930728 | 0.91 | ALDH1A1 (0.70) | ALDH1A1TSHRMCL1LMNAHDAC8 | |
| Styrene SCHEMBL3693751 | 0.91 | ALDH1A1 (0.70) | ALDH1A1TSHRMCL1LMNAHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100986-A1 | BIOCIDAL COMPOSITIONS FOR PLASTICS | BASF SE (DE) | 2009-08-20 | — | — | WO | disclosed |
| US-5477652-A | Composite security wall systems | GENERAL ELECTRIC COMPANY (US) | 1995-12-26 | — | — | US | disclosed |