Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CCL2 | P13500 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5695982 | 0.92 | BRD4 (0.37) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL29424565 | 0.92 | HTR2A (0.39) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL137960 | 0.92 | HTR2A (0.39) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL28189655 | 0.90 | BRD4 (0.36) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL30533388 | 0.90 | HTR2A (0.38) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL820052 | 0.90 | HTR2A (0.38) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| SCHEMBL31357303 | 0.90 | HTR2A (0.40) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7933121 | 0.90 | BRD4 (0.32) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7622358 | 0.89 | BRD4 (0.35) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5699505 | 0.89 | BRD4 (0.35) | BRD4CCL2HTR2AHTR6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107488242-A | Use micro passage reaction and metallocene catalysis system polymeric linear alhpa olefin method | 上海纳克润滑技术有限公司 | 2017-12-19 | — | — | CN | claimed |
| CN-107488242-A | Use micro passage reaction and metallocene catalysis system polymeric linear alhpa olefin method | 上海纳克润滑技术有限公司 | 2017-12-19 | — | — | CN | disclosed |
| US-20140200317-A1 | Methods for Reducing Static Charge of a Catalyst and Methods for Using the Catalyst to Produce Polyolefins | UNIVATION TECHNOLOGIES, LLC (US) | 2014-07-17 | — | — | US | disclosed |
| US-8722820-B2 | Methods for reducing static charge of a catalyst and methods for using the catalyst to produce polyolefins | UNIVATION TECHNOLOGIES, LLC (US) | 2014-05-13 | — | — | US | disclosed |
| US-20130085245-A1 | Methods for Reducing Static Charge of a Catalyst and Methods for Using the Catalyst to Produce Polyolefins | UNIVATION TECHNOLOGIES, LLC (US) | 2013-04-04 | — | — | US | disclosed |
| EP-2510019-A2 | METHODS FOR REDUCING STATIC CHARGE OF A CATALYST AND METHODS FOR USING THE CATALYST TO PRODUCE POLYOLEFINS | Univation Technologies, LLC (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011071900-A2 | METHODS FOR REDUCING STATIC CHARGE OF A CATALYST AND METHODS FOR USING THE CATALYST TO PRODUCE POLYOLEFINS | UNIVATION TECHNOLOGIES, LLC (US) | 2011-06-16 | — | — | WO | disclosed |