Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 9/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.52 |
| ▸ | GABRP | O00591 | 7/20 | 0.52 |
| ▸ | GABRD | O14764 | 7/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.52 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.52 |
| ▸ | GABRE | P78334 | 7/20 | 0.52 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.52 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.52 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.52 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979008 | 0.84 | ALDH1A1 (0.66) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1980496 | 0.78 | GABRA1 (0.52) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1979521 | 0.77 | PIM1 (0.50) | MAPTACHE | |
| SCHEMBL1981906 | 0.73 | GABRA1 (0.52) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10642293 | 0.70 | GABRP (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10644702 | 0.69 | GABRA1 (0.79) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1980977 | 0.67 | ALDH1A1 (0.66) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1983604 | 0.67 | ALDH1A1 (0.66) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1980018 | 0.67 | KDM1A (0.34) | KDRETV6LMNA | |
| SCHEMBL1981698 | 0.66 | GABRA1 (0.63) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |