Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 17/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.80 |
| ▸ | MAPT | P10636 | 11/20 | 0.80 |
| ▸ | HPGD | P15428 | 10/20 | 0.80 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.80 |
| ▸ | TP53 | P04637 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | HTT | P42858 | 5/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 7/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | EEF2K | O00418 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20467123 | 0.81 | KDM4E (0.67) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL427370 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL12562437 | 0.77 | KDM4E (0.81) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL12818768 | 0.74 | IKBKB (0.64) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL2614845 | 0.73 | ALDH1A1 (0.66) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL19805194 | 0.72 | ALDH1A1 (0.71) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL20467122 | 0.70 | GUSB (0.87) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL8272436 | 0.69 | ALDH1A1 (0.51) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL2614847 | 0.68 | LMNA (0.61) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL1320500 | 0.68 | ALDH1A1 (0.66) | KDM4EALDH1A1MAPTHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339178-B2 | Inhibitors of microbial beta-glucuronidase enzymes and uses thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2022-05-24 | — | — | US | disclosed |
| US-20190330237-A1 | INHIBITORS OF MICROBIAL BETA-GLUCURONIDASE ENZYMES AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2019-10-31 | — | — | US | disclosed |
| WO-2018142365-A1 | INHIBITORS OF MICROBIAL BETA-GLUCURONIDASE ENZYMES AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2018-08-09 | — | — | WO | disclosed |
| WO-2018017874-A1 | INHIBITORS OF MICROBIAL BETA-GLUCURONIDASE ENZYMES AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2018-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11339178-B2 | Inhibitors of microbial beta-glucuronidase enzymes and uses thereof | GUSB, ENGASE, MGAM | KDM4E 4075/4885ALDH1A1 511/4885MAPT 768/4885 |
| US-20190330237-A1 | INHIBITORS OF MICROBIAL BETA-GLUCURONIDASE ENZYMES AND USES THEREOF | GUSB, ENGASE, MGAM | KDM4E 4075/4885ALDH1A1 511/4885MAPT 768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.