Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.38 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1980560 | 1.00 | CTSS (0.41) | CTSSCTSKTLR7TLR8KMT2A | |
| SCHEMBL1982922 | 0.88 | HTR2B (0.46) | CTSSCTSKTLR7TLR8KMT2A | |
| SCHEMBL1982924 | 0.88 | HTR2B (0.46) | CTSSCTSKTLR7TLR8KMT2A | |
| SCHEMBL1981327 | 0.85 | DPP4 (0.42) | TLR7TLR8KMT2ATLR9SMN1; SMN2 | |
| SCHEMBL1981326 | 0.85 | DPP4 (0.42) | TLR7TLR8KMT2ATLR9SMN1; SMN2 | |
| SCHEMBL27878469 | 0.85 | TLR7 (0.37) | TLR7TLR8KMT2ACYP51A1TLR9 | |
| SCHEMBL27878467 | 0.83 | TLR7 (0.37) | TLR7TLR8TLR9SMN1; SMN2ALDH1A1 | |
| SCHEMBL1980796 | 0.78 | TLR7 (0.53) | TLR7TLR8KMT2AABCB1MEN1 | |
| SCHEMBL1980818 | 0.76 | CTSK (0.43) | CTSSCTSKKMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL1980816 | 0.76 | CTSK (0.43) | CTSSCTSKKMT2ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513054-B1 | BICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-09 | — | — | EP | disclosed |
| US-8552032-B2 | Bicyclic derivatives useful as inhibitors of DPP-1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-10-08 | — | — | US | disclosed |
| US-20110152321-A1 | BICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 | JANSSEN PHARMACEUTICA (BE) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152321-A1 | BICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 | DPP4, DPP7, DPP3 | CTSS 966/4885CTSK 1284/4885TLR7 4146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.