Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 9/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22912209 | 0.84 | SDHB (0.48) | SDHBHPGDTP53KDM4EUSP2 | |
| SCHEMBL19805988 | 0.82 | SDHB (0.53) | SDHBHPGDMAPTALDH1A1PDE2A | |
| SCHEMBL19806088 | 0.80 | SDHB (0.54) | SDHBMAPTPDE2APDE3ATP53 | |
| SCHEMBL22912277 | 0.79 | SDHB (0.48) | SDHBMAPTPDE2APDE3ATP53 | |
| SCHEMBL19805996 | 0.77 | SDHB (0.46) | SDHBMEN1KMT2AMAPTPOLB | |
| SCHEMBL19805843 | 0.75 | SDHB (0.55) | SDHBMAPTPDE2APDE3ATP53 | |
| SCHEMBL21019832 | 0.74 | SDHB (0.66) | SDHBKMT2AHPGDALDH1A1POLB | |
| SCHEMBL20985729 | 0.73 | SDHB (0.81) | SDHBKMT2AALDH1A1POLBGAA | |
| SCHEMBL22912195 | 0.72 | SDHB (0.63) | SDHBMEN1KMT2AHPGDMAPT | |
| SCHEMBL26313170 | 0.72 | MKNK1 (0.46) | SDHBMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018014802-A1 | APOPTOSIS INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-01-25 | — | — | WO | disclosed |