Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 12/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | MPO | P05164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21010418 | 0.84 | TRPA1 (0.43) | TRPA1FGFR1DGAT1MPO | |
| SCHEMBL19807684 | 0.84 | TRPA1 (0.45) | TRPA1FGFR1DGAT1 | |
| SCHEMBL20997476 | 0.84 | TRPA1 (0.45) | TRPA1FGFR1DGAT1 | |
| SCHEMBL19807681 | 0.81 | TRPA1 (0.41) | TRPA1FGFR1MPO | |
| SCHEMBL17979414 | 0.80 | TRPA1 (0.46) | TRPA1FGFR1 | |
| SCHEMBL19807437 | 0.80 | TRPA1 (0.52) | TRPA1FGFR1DGAT1 | |
| SCHEMBL18017677 | 0.77 | TRPA1 (0.46) | TRPA1FGFR1DGAT1 | |
| SCHEMBL19795020 | 0.77 | TRPA1 (0.39) | TRPA1FGFR1DGAT1 | |
| SCHEMBL19795019 | 0.72 | PTGS2 (0.37) | TRPA1FGFR1DGAT1 | |
| SCHEMBL3332657 | 0.69 | POLB (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10766878-B2 | Sulfonylcycloalkyl carboxamide compounds | GENENTECH, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-20190144430-A1 | SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS | GENENTECH, INC. (US) | 2019-05-16 | — | — | US | disclosed |
| WO-2018015411-A1 | SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS AS TRPA1 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144430-A1 | SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS | TRPA1, TRPV1, TRPV5 | TRPA1 1/4885FGFR1 315/4885DGAT1 1478/4885 |
| US-10766878-B2 | Sulfonylcycloalkyl carboxamide compounds | TRPA1, TRPV1, TRPV5 | TRPA1 1/4885FGFR1 315/4885DGAT1 1478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.