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Sugi Predict / Compounds / Tyrosine

Tyrosine

Tyrosine

SCHEMBL19809043

CC(C)C(NC(=O)C(N)CCC(=O)O)C(=O)O.NC(Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 1/20 0.56
▸ NAALAD2 Q9Y3Q0 1/20 0.48
▸ BACE1 P56817 8/20 0.47
▸ BACE2 Q9Y5Z0 3/20 0.47
▸ OPRD1 P41143 4/20 0.46
▸ YARS1 P54577 2/20 0.46
▸ DPP4 P27487 1/20 0.44
▸ DPP8 Q6V1X1 1/20 0.44
▸ DPP9 Q86TI2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL19809042 1.00 SLC7A5 (0.56) SLC7A5NAALAD2BACE1BACE2OPRD1
SCHEMBL29531717 0.91 BACE1 (0.56) NAALAD2BACE1BACE2OPRD1
SCHEMBL30947373 0.89 OPRD1 (0.53) NAALAD2BACE1BACE2OPRD1
SCHEMBL29462561 0.88 SLC7A5 (0.59) SLC7A5OPRD1YARS1
SCHEMBL29531284 0.88 SLC7A5 (0.59) SLC7A5OPRD1YARS1
Hydrochloric Acid SCHEMBL30698094 0.86 SLC7A5 (0.58) SLC7A5OPRD1YARS1
SCHEMBL31276527 0.85 SLC7A5 (0.56) SLC7A5OPRD1YARS1
Tyrosine SCHEMBL1495262 0.84 NAALAD2 (0.64) SLC7A5NAALAD2BACE1BACE2YARS1
SCHEMBL29832294 0.84 BACE1 (0.66) BACE1BACE2OPRD1
SCHEMBL31062518 0.84 OPRD1 (0.61) SLC7A5BACE1BACE2OPRD1YARS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2930512-B1 Biomarkers for fatty liver disease and methods using the same METABOLON INC (US) 2018-01-31 — — EP disclosed
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