SCHEMBL1980989

SCHEMBL1980989

O=c1[nH]c2ccc3ccoc3c2[nH]1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 4/20 0.39
MAOB P27338 2/20 0.39
PDE3B Q13370 1/20 0.35
PDE3A Q14432 1/20 0.35
HTR2A P28223 1/20 0.34
HTR2C P28335 1/20 0.34
HTR2B P41595 1/20 0.34
NFKB1 P19838 2/20 0.33
CYP1A2 P05177 2/20 0.32
CYP3A4 P08684 2/20 0.32
CYP2D6 P10635 2/20 0.32
CYP2A6 P11509 2/20 0.32
ACHE P22303 2/20 0.32
CYP2C19 P33261 2/20 0.32
SIRT2 Q8IXJ6 1/20 0.32
TSHR P16473 1/20 0.32
PDE4A P27815 1/20 0.32
MAPK1 P28482 1/20 0.32
SLC6A3 Q01959 1/20 0.32
CYP2A13 Q16696 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL473556 0.68 KDM4E (0.42) PDE3BPDE3AKDM4EGAA
SCHEMBL4426880 0.68 TNF (0.39) MAOAMAOBHTR2AHTR2CHTR2B
SCHEMBL11829893 0.68 MAOA (0.37) MAOAMAOBHTR2AHTR2CHTR2B
SCHEMBL29591293 0.67 MAOA (0.46) MAOAMAOBHTR2AHTR2CHTR2B
SCHEMBL4419988 0.67 MAOA (0.46) MAOAMAOBHTR2AHTR2CHTR2B
SCHEMBL8821629 0.65 MAOA (0.41) MAOAMAOBHTR2AHTR2CHTR2B
SCHEMBL1838221 0.65 KDM4E (0.61) PDE3BPDE3ACYP2A6SIRT2TSHR
SCHEMBL15200583 0.64 KIF11 (0.58) MAOAHTR2BNFKB1CYP1A2CYP3A4
SCHEMBL660982 0.64 PARP1 (0.42) MAOAMAOBHTR2AHTR2CHTR2B
SCHEMBL14648524 0.62 ADRB2 (0.40) MAOAMAOBHTR2AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2718276-A1 HETEROCYCLIC SULFONAMIDE DERIVATIVES Novartis AG (CH) 2014-04-16 EP disclosed
WO-2012168884-A1 HETEROCYCLIC SULFONAMIDE DERIVATIVES NOVARTIS AG (CH) 2012-12-13 WO disclosed
EP-2509964-A1 HETEROCYCLIC SULFONAMIDE DERIVATIVES Novartis AG (CH) 2012-10-17 EP disclosed
WO-2011070030-A1 HETEROCYCLIC SULFONAMIDE DERIVATIVES NOVARTIS AG (CH) 2011-06-16 WO disclosed